Amlodipine Besylate is a class of calcium channel blockers. It is used to treat hypertension (high blood pressure). Amlodipine acts on blood vessels and expands the blood vessels more than usual and decreases blood pressure (as we know area is inversely proportional to pressure). Lowering hypertension also reduces the risk of cardiovascular events, strokes and some other problems. One of the Amlodipine product on the market is Norvasc.

Amlodipine Besylate API

CAS Number: 111470-99-6

Molecular Weight: 567.05

Melting point: 199-201°C

Storage Temperature: Store at RT

Mechanism of action:

Amlodipine Besylate prohibits the transmembrane influx of calcium ions into the vascular smooth and cardiac muscle.

Amlodipine Besylate is a dihydropyridine calcium antagonist that attaches to both dihydropyridine and non-dihydropyridine binding sites. The contractile manners of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells through specific ion channels.

Amlodipine Besylate prohibits calcium ion influx across cell membranes selectively, with a superior effect on vascular smooth muscle cells than on cardiac muscle cells.  It is more selective for vascular smooth muscle than for the cardiac muscle. 

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